So here is an idea that I have been thinking about. It all started with my mentor, Dr. Booth, getting really excited about a paper in 2006 by Raymond and Segre appearing in Science. Although the details were difficult to understand his interpretation was clear, physical activity was key to the development of complex metabolic pathways early in life.
Here is the jest of the argument. Once photosynthesis evolved in bacteria (the process of using sunlight, water, and carbon dioxide to make energy and oxygen) the amount of gaseous oxygen in the atmosphere increased dramatically. Back then oxygen was toxic to most organisms and there were multiple was organisms could respond to this rise in oxygen. They could 1) Hide, 2) Adapt, or 3) Perish. Well a group adapted (likely by chance since evolution is not forward thinking) by being able to use oxygen as the final electron acceptor in aerobic respiration. The consequences of this cannot be understated, oxygen with a huge electronegative potential allowed for 4 times as much energy produced from a molecule of glucose over any other currently used final electron acceptor.

All of a sudden organisms had all this extra energy without having to do anything. Naturally they starting to use this energy for a wide variety biochemical reactions that previously were too energy costly. This is what Raymond and Segre showed, adding oxygen greatly increasing the number and the complexity of biochemical reactions possible. Genomes became more complex, behaviors became more complex, and the diversity of life exploded. It is easy to visualize that being more motile (of physically active) would have allowed organisms to obtain energy easier and avoid predators easier. With their new found extra energy from aerobic respiration this likely happened. Once they became more physically active then the biochemical pathways for those actions would have further developed, meaning physical activity actually selected certain genes and behaviors to develop. Amazing.
It then does not come as much of a surprise that physical activity is important for our health today. Just think about it’s beginnings.
Posted by mjlaye 